Women are always concerned about their appearance compared to men. Of course, nowadays we see more men in salons compared to yesteryears, but the ratio is still higher in the case of women. This concern makes a woman approach a doctor immediately if she notices any changes or rashes in the skin. Women are better protected than men against a deadly form of skin cancer called melanoma that develops from pigment-producing cells called melanocytes.
Few reasons that contribute to the cause of more men being affected by this cancer than women include:
The question here is whether men can also benefit from the effect of estrogen? While there are already few evidences that support the fact that estrogen might benefit men with melanoma, studies show that obese men with melanoma have better response and survival rate to therapy than those with a normal body mass index. This might be because fat tissue produces estrogen and obese men have increased estrogen levels in their blood. But, the same effect was not seen in the case of obese women, suggesting a hormonal link.
Hence, estrogen and G-protein coupled estrogen receptor (GPER)-activating drugs might play a pivotal role in improving outcomes in melanoma patients. When these drugs are used along with existing treatment options, they might make immunotherapies even more effective in patients.
Dietitian & Nutritionist Dr. Nafeesa Imteyaz.