The joy has no bounds when you realize that you are pregnant and your spouse is equally elated. Life is a giant wheel ride where you reach for the stars sometimes or lick the mud at other times! It doesn’t come with a guarantee or a warrantee. So, when someone who has just started enjoying marital bliss gets pregnant unexpectedly (couples spend more time planning for when to conceive these days) or when couples who are already parents of two kids conceive despite protection using contraceptives there arises the usual blame game-spouses blaming each other for being careless about birth control pills or even missing to take the dose! The family goes through emotional breakdowns, arguments, hard feelings and more when a decision regarding the fetus must be made. Actually, it might be the work of your naughty genes that affects your contraception and induces pregnancy. Pregnancy is a blessing and many couples these days fail to conceive naturally. Why don’t you meet RDNs at www.firsteatright.com if you face difficulties trying to conceive naturally as they are always there to help you in a scientific and practical way.
Contraceptive’s Effectiveness Too in your Genetic Makeup?
When a woman comes and broods over her pregnancy despite being on birth control pills the physician always gives some justification for the failure of the pill, all of it normally blamed onto the woman-maybe she did not take her pill, her method of usage was wrong or something else wasn’t as per plan! But some researchers were not for this and they wanted to find out if there were any other contributing factors for such disturbing effects.
There hasn’t been much probing onto this field of a woman’s health and its high time that we start looking out for all other possibilities. To set off the initiative, a group of researchers had 350 women (most of them were in their early 20s) volunteers go for an etonogestrel implant for at least a minimum of 12 months and not more than 36 months. This implant is a small plastic strip inserted into the woman’s skin which releases hormones that prevent pregnancy over the entire course of the 36-month period. The research team measured every woman’s blood concentration of etonogestrel and also sampled her DNA for any specific genetic variants, more specifically on the CYP3A7*1C that could affect hormonal metabolism. The CYP3A7*1C gene is active only in the fetal stage but never during the infant stage. It codes for a protein namely the CYP3A7 during the initial stages of fetal development but later it becomes dormant and gene turns dormant later preventing the expression of the enzyme. But in men and women with the variant, enzyme production continues and the gene never becomes dormant.
Researchers found that in their study almost 1 in every 4 women with the CYP3A7*1C genetic variant did not have enough etonogestrel levels to prevent fertilization. Those with a higher body mass index (BMI) and a longer implant use had lower blood concentrations of the hormone.
This research takes upon an important place in the history of contraceptive pills as hormonal contraception has been used for centuries worldwide. We all know that the same pill doesn’t work the same way in two different people and it can also cause different side effects in each of them. It might even have beneficial effects on a lady while the other one despises taking it every day in life.
Identifying women who had become pregnant by chance gives the researchers a ticket to really identify who might be at a risk of pregnancy even after taking the pill. Its high time we understand that there are factors beyond missing pills or improper use, such as genetics, that play an important role in handling effective birth control in the woman. This is a great step towards better future research.
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